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Using Pause Information for More Accurate Entity Recognition ...
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Using Pause Information for More Accurate Entity Recognition ...
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The Role of Surface and Underlying Forms When Processing Tonal Alternations in Mandarin Chinese: A Mismatch Negativity Study
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A simple and effective method to discern the true commercial Chinese cordyceps from counterfeits
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Detecting integration of top-down information using the mismatch negativity: Preliminary evidence from phoneme restoration
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The Role of Surface and Underlying Forms When Processing Tonal Alternations in Mandarin Chinese: A Mismatch Negativity Study
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Additional file 1: of SWOT analysis on snail control measures applied in the national schistosomiasis control programme in the Peopleâ s Republic of China ...
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Additional file 1: of SWOT analysis on snail control measures applied in the national schistosomiasis control programme in the Peopleâ s Republic of China ...
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Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism
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Wu, Jia-shun; Zheng, Min; Zhang, Mei; Pang, Xin; Li, Li; Wang, Sha-sha; Yang, Xiao; Wu, Jing-biao; Tang, Ya-jie; Tang, Ya-ling; Liang, Xin-hua. - : Frontiers Media S.A., 2018
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Abstract:
Microbiota has been widely considered to play a critical role in human carcinogenesis. Human papilloma virus, hepatitis B and C virus, and Helicobacter pylori are implicated in the pathogenesis of cancer of uterine cervix, liver, and stomach, respectively. However, whether Porphyromonas gingivalis (P. gingivalis), a common Gram negative oral bacteria, is associated with oral carcinogenesis still remains unclear and its underlying mechanism needs to be addressed. Here, we established a combined experimental system of 4NQO-induced oral carcinoma model and chronic periodontitis model and investigated the effects of P. gingivalis infection on oral carcinogenesis and fatty acid metabolism during oral carcinogenesis. The data showed that in this animal model, P. gingivalis infection induced mice periodontitis, increased the tongue lesion size and multiplicity of each mouse and promoted oral cancer development. P. gingivalis treatment significantly increased the level of free fatty acids and altered the fatty acid profile in tongue tissues and the serum of mice. And P. gingivalis induced the formation of fatty liver of the mice. Besides, immunohistochemical analysis and qRT-PCR showed that the expression of fatty-acid synthase and acetyl-CoA carboxylase 1 were increased in the tongue and liver tissues of 4NQO-treated mice infected with P. gingivalis. These results showed that P. gingivalis promoted oral carcinogenesis and aggravated disturbance of fatty acid metabolism, indicating a close association among P. gingivalis, lipid metabolic and oral carcinogenesis.
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Keyword:
Microbiology
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131559/ https://doi.org/10.3389/fmicb.2018.02081
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Additional file 1: of Low activity of complement in the cerebrospinal fluid of the patients with various prion diseases ...
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Additional file 1: of Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone ...
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Additional file 1: of Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone ...
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Additional file 1: of Low activity of complement in the cerebrospinal fluid of the patients with various prion diseases ...
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Analysis of potential dynamic concealed factors in the difficulty of lower third molar extraction
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In: Singh, Pradeep ; Ajmera, Deepal-Haresh ; Xiao, Shui-Sheng ; Yang, Xiao-Zhu ; Liu, Xiong ; Peng, Bin. Analysis of potential dynamic concealed factors in the difficulty of lower third molar extraction. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 21 6 2016: 4- (2016)
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More Dialectical Thinking, Less Creativity? The Relationship between Dialectical Thinking Style and Creative Personality: The Case of China
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Relationship between holistic rating of Chinese ESL speakers' monologue responses to question prompts in placement testing and their lexical frequency profiles
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In: Open Access Theses (2014)
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Relationship between holistic rating of Chinese ESL speakers' monologue responses to question prompts in placement testing and their lexical frequency profiles
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In: Theses and Dissertations Available from ProQuest (2014)
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Older Chinese Australians' Understanding of Falls and Falls Prevention: Exploring Their Needs for Information
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